MTP 018 AStandard and Difficult-to-Control Asthma: The Asthma Expert's ToolboxClinical questions to be addressed:How should asthma therapy be escalated if patients fail to improve?What potential exacerbating factors should be sought out?Are long-acting beta-agonists safe?When should such approaches, as immunotherapy, anti-IgE therapy, or bronchial thermoplasty be considered?