MTP 086 Clinical questions to be addressed: What are common extra-articular causes of pain in patients with OA? How much pain relief should be expected from medications? How do I interpret the results of clinical trials in OA? What are your specific recommendations for use of intra-articular and non-traditional pharmacologic therapies? Can I still use NSAIDs? What alternative therapies may be used, and which may be helpful? What more conservative knee conservation surgeries are available for the younger patient? What is the role of complimentary therapy? What is available as "knee conservation" surgery for the younger patient (to delay knee replacement)? What can we expect from weight loss for pain relief?