1. What is a rational approach for selection of empirical therapy of urinary tract infections (quinolones vs. sulfonamides)? 2. When is antimicrobial therapy appropriate for upper respiratory tract infection and sinusitis? 3. What is the appropriate evaluation, management, and antibiotic options for skin and soft tissue infection in the era of community-acquired MRSA? 4. What antimicrobial regimens are effective in the era of quinolone-resistant gonorrhea?