Clinical questions to be addressed:How can the clinician assess the potential risk for breast cancer in a healthy woman? What models are available to assess the risk of her harboring a breast cancer gene mutation?What are the currently available therapies for the prevention of breast cancer, and when should they be used?What new developments in breast cancer screening for high-risk women are now available?What should an internist know about breast cancer genes, genetics testing, and the counseling of women who are being tested for the breast cancer genes?