Clinical questions to be addressed:In which patients does asymptomatic isolated proteinuria require evaluation? Has the evaluation changed in recent years?What is the evaluation of a patient with a creatinine slightly above the upper limit of normal?What is the best approach to preserving renal function in patients with chronic kidney disease?How high a phosphate is "too high"? How low a calcium is "too low"?How can the internist optimize cardiovascular risk in patients with chronic kidney disease?What is the evaluation and treatment of anemia in patients with chronic kidney disease?