MTP 043 Clinical questions to be addressed: Who should get PSA screening, and at what age? Is the level or rate of change of PSA important in determining who should be further evaluated? When you decide that a patient without known prostate cancer with a rising screening PSA should be evaluated, what should be done and by whom? What is the management of a patient with a known history of prostate cancer who has a rising PSA but negative scans? What are the short- and long-term effects of anti-androgen therapy?