MTP 055 Clinical questions to be addressed: What are the immunocompromising effects of immunomodulating agents, such as antilymphocyte agents (rituximab and alemtuzumab); tumor necrosis factor (TNF)--inhibiting agents, such as etanercept and infliximab; monoclonal antibody against TNF, such as adalimum? Which pathogens and infections should be suspected in patients with these immunodeficiencies? What are the infectious disease--associated treatment regimens and prevention strategies (including immunizations) for patients who are receiving these agents?